Senators to Dr. Oz: Stop Promising Weight-Loss Miracles
Can low thyroid function cause weight gain?
The thyroid gland is a small, butterfly-shaped gland that normally weighs less than one ounce, and is located in the neck under your voice box. The hormones that your thyroid produces help to regulate your metabolism, affecting how smoothly and quickly your body can convert calories into energy. This then has a direct impact on how much fat you store.
Causes of low thyroid function can include your diet, a hereditary condition, hormonal changes or even a food allergy. Some symptoms are weight gain, fluid retention, low body temperature (you're always cold when everyone else is not), dry skin, brittle nails, constant fatigue, depression, difficulty getting pregnant and acne.
If you've noticed any changes in weight, mood, and energy levels ask your doctor to run some thyroid blood tests. Since low thyroid function is not fully understood by medical professionals, getting a diagnosis is not always as straightforward as you would think. It is important to find a doctor with an open mind, who is willing to examine all evidence (including your own thoughts) and who will work with you towards a diagnosis.
Here are a few diet and lifestyle choices that can help boost your thyroid gland naturally:
- Increasing your Iodine intake can help stimulate thyroid gland function. The thyroid gland is responsible for regulating body metabolism and energy expenditure. Kelp extract supplements are a potent source of Iodine, as well as all different types of seaweeds and seafood.
- Spicy food doesn't just taste great, it actually increases your metabolism too. Black Pepper, Ginger, Chili Peppers and Cinnamon all raise your body temperature, increase your circulation and help you burn fat faster!
- Eating more fiber. Constipation is very common symptom of hypothyroidism, so it's important to get enough sources of fiber to keep things moving. Great sources are brown rice, brown rice pasta, oats, beans, apples, oranges, and dried apricots.
- It’s a fact that most of us do not get enough Omega-3 oils in our diet to maintain optimum thyroid health. Deficiencies of this fatty acid have actually been linked to lower thyroid hormone levels. Good sources of this metabolism-boosting acid are flax seed, acai berry, hemp seeds, pumpkin seeds, salmon, mackerel, sardines and herring. Many people use flax oil and acai berry as a supplement.
- Without adequate protein the thyroid can't function properly, even if the sufferer is taking suitable thyroid medication. Make sure you get enough lean meats, fish, poultry and low fat dairy products or eggs.
Trans Fats and weight gain
Trans Fat (hydrogenated fat) is manufactured by adding hydrogen to vegetable oils in a process called hydrogenation, which gives it a solid consistency. It is used to fry fast foods including chicken, in addition to being present in cookies, pizza, margarine and hidden in many other foods.
Trans Fat is widely used in junk foods (and even some so called 'health food') thanks to a number of qualities that make it very appealing to food manufacturers. It's cheap to produce, extends the shelf life of food and helps create a very appealing texture in the mouth.
Weight Gain
Research is now starting to show that Trans Fat is more associated with weight gain than other fats. Trans fat is not metabolized the same way that good fats are. It causes an inflammation response to the body, which increases cortisol and blood glucose levels, and also inhibits insulin function."Trans Fat is worse than anticipated," according to Wake Forest researcher Lawrence L. Rudel, PhD. "Diets rich in Trans Fat cause a redistribution of fat tissue into the abdomen and lead to a higher body weight, even when the total dietary calories are controlled."
So the effect of junk food on your weight is greatly increased - not only is it high calorie, but the Trans Fat that it contains actually accelerates your weight gain even further!
Health concerns
The reputation of this 'Frankenstein fat' has gone from bad to worse. Places like Switzerland, Denmark and New York have already started regulating Trans Fat content, due to concern for their citizens' health.Trans Fats raise your bad (LDL) cholesterol levels and lower your good (HDL) cholesterol levels. This type of artery-clogging fat may also be responsible for increases in heart disease, strokes, type 2 diabetes, cancer and low birth rates. This is not even the entire list of health issues many recent studies are uncovering.
How can you avoid Trans Fat?
Depending on where you live, it can actually be very easy to avoid Trans Fat. If you live in New York for example, regulations ensure that restaurant food will have minimal levels. However, even a trip to the supermarket can expose you to high levels of this nasty substance.When you pick up food, check the list of ingredients for Trans Fats. They also goes by the names of 'hydrogenated oil', 'vegetable shortening' or 'partially hydrogenated oil'. Here is a small list of some of the main culprits:
- French fries
- Biscuits, cookies
- Cakes, pastries, doughnuts
- Breakfast cereals
- Cereal bars
- Fried chicken, and other fast food
- Pizza
- Microwave popcorn
- Frozen foods
- Vegetable shortening and margarine
Why Beans are a Great Weight Loss Food!
They're the ultimate convenience food too, and can really help stretch the smallest of food budgets.
Beans are a high source of fiber, which is really important to stay slim but also wards off the risk of colon cancer too. It is recommended that women consume between 25-30 grams of fiber a day. However, most of us consume only half of that, leaving many of us chronically constipated, fatigued, and frustrated by our inability to lose weight. The good news is that, with a little imagination, beans can play a tasty and important role in your weight loss goals.
Consuming adequate fiber is essential for any weight loss plan, for two reasons. The high fiber content in beans makes you feel full and satisfied for longer. This stabilizes your blood sugar levels and reduces your appetite, both vital factors for losing weight. Another added bonus is that beans are high in soluble fiber, which can help to reduce bad cholesterol levels.
Beans are often overlooked as a quality source of low fat protein. When combined with whole grains such as brown rice, beans provide a quality heart-healthy complete protein, but without the saturated fat of animal protein. A lot of dieters stick to high animal protein diets which can be helpful for weight loss. However these animal sources provide no fiber, so dieters end up constipated. The fat content in animal protein can easily end up being stored by your body, whereas if you eat too much vegetable protein, it is simply eliminated by your body as waste. There is a place in the diet for lean cuts of animal meat and dairy, but substituting beans for meat at a few meals will be great for your health.
Cooking beans is easy, although you can even just use canned beans. Just be sure to buy the low sodium variety and rinse the beans well. Also don't go crazy right away on beans - give your digestive system a little time to adjust. Introduce them gradually until your body gets used to them.
Some bean recipes to try..
Chickpea Salad
1 onion
1 tomato
Black olives
Basil
Chopped fresh chilies or chili flakes
2 tablespoon olive oil
Chop it all up, mix it together and serve.
Lima Bean Hummus
1/3 cup lemon juice
1 to 2 cloves minced garlic
1/2 teaspoon ground cumin
1/4 cup finely minced parsley leaves
1 tablespoon paprika
Salt
This is a great, low fat, hummus snack. The lima beans are an excellent source of Tyrosine and will stabilize your blood sugar levels.
Just take all the above ingredients (except the parsley) and blend until pureed. Then take out of the blender and mix in the parsley leaves, and leave in the refrigerator for a few hours. Lastly, add the paprika as a garnish and serve with chopped vegetables like carrots or celery.
How To Get Rid Of Your Cellulite
The best thing is that many modeling jobs don’t even need you to expose your legs, and remember it’s a quick fix on Photoshop anyway! But you can also reduce the amount you have by making a few dietary changes, in conjunction with exercise and skin brushing, and that’s what this page is all about.
So what is Cellulite? Cellulite is a mixture of trapped fat, toxins and water that affects females of all shapes and cultures after puberty. Genetic predisposition certainly plays a role in cellulite, however a great place to start in the fight against cellulite is by cleaning up your diet. An overall reduction of fat will help shift those pesky dimples. These tips will not only help you to avoid cellulite, but also will also improve overall health.
Hydration
You should aim to drink around 8-10 glasses of water a day to keep your metabolism revved up and ensure that at least some of that fat will not stick around. If you aren’t a fan of drinking loads of water, add a little bit of fresh juice or lemon to the water to add flavor and up you intake of fruits and vegetables.
Skin Brushing
Start the skin brushing with the soles of your feet, using slow, gentle, circular movements. Move up your body, all the time brushing towards your chest, but be careful to avoid areas where your skin is particularly sensitive.
If this habit seems like too much of a chore, the easier way to attain the same effect is to get weekly massages!
Cellulite Diet 'No-No’s
- Coffee
Sorry, but that means all caffeinated beverages, sodas and energy drinks! It is believed that caffeine constricts blood vessels, thereby reducing the blood and oxygen circulation to cells and damaging the connective tissue. While we're on the subject of unhealthy habits, cigarettes do pretty much the same thing.- Alcohol
- Junk food
Processed food is full of preservatives, sweeteners, and salt. Sometimes these substances just can’t be processed by your internal organs, and your body’s defense mechanism is to lock them away in fat cells.One of the main ingredients in junk food in trans fat, found in partially hydrogenated oil, margarine, and vegetable shortening. Studies have recently shown that trans fat is metabolized differently than good fats, and results in more weight gain. It causes an inflammation response within the body, which increases cortisol and blood glucose levels, inhibits insulin function, and increases your fat and cellulite.
Eating foods containing trans fat is basically like eating plastic, so try to avoid it! This means cookies, cakes, donuts, most crackers, french fries, frozen meals and many packaged foods. Here’s the key lesson you need to remember - check labels and make sure the foods you eat contain zero trans fats!
- Sugar (and foods that break down to sugar)
Another enemy in your battle against cellulite is sugar. By that I mean sugar itself, or other foods that convert to glucose. Some of this glucose is used immediately by your body, but a small amount is converted to glycogen and is stored in the muscles and liver. When these organs are full, any excess goes straight to your fat cells and can appear as cellulite.Its not just the obvious foods that contain refined sugar (e.g. soda, candy) that you need to watch out for. Refined carbs such as white bread, white pasta and white rice are just as bad. So lay off the desserts and switch to wholewheat bread and pasta.
Cellulite-Busting Foods
- Proteins
Its not all about the foods that you need to avoid. Protein is the most important building block for collagen and elastin.fibers, both essential for the health of your skin. If you feed your body the right things, your cellulite will become less obvious and may start to clear up altogether. Choose lean cuts of meat and poultry, eggs, and fish, milk and yogurt, beans, and nuts.- Vitamin C
- Good Fats
Not all fats are bad. In fact, eating the right kind can hydrate your skin, keeping it youthful and making your cellulite a lot less visible. Here’s a list of food that are great sources of good fats - flax, hemp seeds, walnuts, pumpkin seeds, olive oil, avocados, salmon, mackerel and herring.And if all else fails...
While following these tips should make a big difference, there’s always one other solution you can fall back on. One of the tricks of the trade is self tanner - it makes your legs appear leaner and longer, and makes cellulite less obvious too!15 EASY TIPS TO GET MOVING AND BURN CALORIES
It’s time to kick-start your weight loss and fat-burning power with some activities of daily living! Don’t think of it as “Exercise” – think of it as “Moving more”! (Tip continues below)
1. Take the stairs instead of the elevator. 2. Park car farther away from your destination. 3. Get off bus or train one stop earlier and walk. 4. Walk up and down escalators. 5. Walk to a co-worker's office instead of emailing. 6. Convert coffee breaks into walking breaks. 7. Pace while talking on the phone (using cordless phone or long handset cord). 8. Take a walk while waiting at the airport or for an appointment. 9. Walk to do your errands instead of drive. 10. When unloading groceries, carry one bag at a time into the house. 11. Walk your child to school. 12. Hide your television remote control. 13. Work in your garden (mowing, raking, weeding, digging, etc). 14. Wash the car yourself instead going to the car wash. 15. Do your own housework (scrubbing, mopping, dusting, polishing, etc). Print off this list and try to do at least two or three of these every day this week. Don’t forget to enter them into your exercise tracker! |
4 FITNESS TIPS FOR THE BUSIEST OF US
You may have the best intentions to exercise regularly, rain or shine, but more than likely life can get in the way and put a damper on your routine. (Tip continues below)
3. Increase accountability. Buddying up with a friend, taking a class or working with a personal trainer are ways you can increase accountability and the likelihood that you will follow through with your program. I recently started working with a personal trainer and found myself to be energized by having someone else checking up on me, making sure I don’t give up and continuing to challenge myself in new ways. If you have a birthday or special event coming up, ask for a gift certificate to a personal trainer. You may be surprised how much more motivated you can be when accountable to someone else. 4. Break a sweat at home. For those busy times when you can’t get to the health club, you need to have some easy ways to get fit at home. Jumping rope, using hand weights or exercise bands or finding fun exercise videotapes or DVD’s are some examples that work well for my patients. If home responsibilities are getting in your way, consider sharing babysitting responsibilities with neighbors or friends so that you can get the time you need to go for a jog, do some yoga or just take a long, warm bath and re-charge your batteries. I hope these four tips will give you new ideas for boosting your fitness, even when life is hectic. |
Classification of Diabetes Mellitus
Diabetes, the Greek word for siphon, in early days, referred to the disease that caused siphoning of the structural components of body into urine. The term "Diabetes Mellitus" (Greek for honey) has been given as urine of a diabetic patient is sweet. Clinically, diabetes mellitus is a heterogeneous primary disorder of carbohydrate metabolism with various etiologic factors, generally involving absolute or relative insulin deficiency or resistance or both. One hallmark of the disease is that it ultimately leads to chronic hyperglycemia. The disease most commonly characterized by frequent urination of the patient, is a complex syndrome that affects multiple organ systems.
Classification
Insulin Dependent Diabetes Mellitus (IDDM) - Type I: Formerly called juvenile-onset or ketosis-prone diabetes and is present in patients with little or no endogenous insulin secretory capacity. These patients develop extreme hyperglycemia, ketosis, and associated symptomatology unless treated with insulin, and they are therefore entirely dependent on exogenous insulin therapy for immediate survival.
Non-Insulin Dependent Diabetes Mellitus (NIDD,V) - Type II : Formerly known as adult-onset, maturity-onset, or nonketotic diabetes. It occurs in patients who retain significant endogenous insulin secretory capacity. Although treatment with insulin may be necessary to control hyperglycemia, these patients do not develop ketosis in absence of insulin therapy and are not dependent on exogenous insulin for immediate survival. Obesity is a frequent feature of NIDDM (obese - 80 per cent, and non-obese -20 per cent), which itself leads to insulin resistance and predisposes or exacerbates the NIDDM state.
Secondary Diabetes :
Many secondary forms of diabetes exist when some other readily identi-fiable primary disease entity or pathophysiologic state is strongly associated with the diabetic state.
- Pancreatic diseases (e.g., pancreatectomy, pancreatic insufficiency, hemochromatosis)
- Hormonal (excess counter insulin hormones, e.g., Cushing's syndrome, acromegaly, pheochro-mocytoma)
- Drug-induced (e.g., thiazide diuretics, steroids, phenytoin)
- Specific genetic syndromes (lipodystrophy, myotonic dystrophy, ataxia-telangiectasia)
Impaired Glucose Tolerance:
Formerly called chemical, latent, borderline, or subclinical diabetes.
Gestational Diabetes :
Glucose intolerance with onset during pregnancy.
Etiology
The etiology of diabetes is far from completely understood. Numerous factors are associated with the development of diabetes. While genetic factors are important in IDDM, they are only predisposing and must interact with environmental influences if diabetes is to develop. If one parent has IDDM, the risk to the offspring of developing IDDM is on the order of 2 to 5 percent. If one child has IDDM, the average risk for another sibling is 5-10 per cent. Genetic susceptibility to IDDM appears to be linked to 2 genes on chromosome 6 that control the production of human lymphocyte antigens (HLA) DR3 and DR4. 95 per cent of IDDM patients have one or both of these antigens compared with 40 per cent of non-diabetic patients. Conversely, patients who carry HLA- DQA1° 0102 or HLA - DQB1° 0602 seem to be protected from the development of IDDM. Emotional and physiologic stress may contribute as precipitating factors in the development of diabetes. Type I patients have a defect in pancreatic b cell function that may be attributed to several causes. Genetic defects in production of certain macro-molecules may interfere with proper insulin synthesis or release, or b cells may not recognize glucose signals or replicate normally. Extrinsic factors that affect b cell function include damage caused by viruses like mumps or Coxsackie B4, by destructive cytotoxins and antibodies released by sensitized lymphocytes, or by autodigestion in the course of an inflammatory disorder involving adjacent exocrine pancreas.
Unlike IDDM, Type II is relatively common in all populations enjoying an affluent life style. This type of diabetes may be present in a subclinical form for years before diagnosis, and the incidence increases markedly with age and degree of obesity. A reduced number of insulin receptors and the problem of insulin binding are major factors in the etiology of NIBDM.
Blood glucose level can be elevated by some hormones and drugs that influence the regulation of blood glucose.
Epidemiology
The prevalence of diabetes differs widely among different populations, depending on ethnic group, age, economical conditions, and other environmental factors. Diabetes mellitus and its complications are now the third leading cause of death in the USA.
Overall, in the USA the prevalence of diabetes is probably between 2 and 4 per cent, with IDDM comprising 7-10 per cent of all cases. Indians, particularly after emigrating from their country, have a higher rate of diabetes than other ethnic groups. Thus, Indians living in South Africa, Trinidad, Singapore, Malayasia, and Fiji exhibit a higher prevalence of diabetes than the local population and than those living in the Indian subcontinent. A low prevalence has been noted in Escimos, Athabascan Indians (Alaska), and Chinese. The proportion of IDDM to NIDDM also differs widely among different populations; IDDM is extremely rare in Pima Indians, Micronesians, and Eskimos, but is more common in Caucasians.2 According to a small group rural study the prevalence of NIDDM in Bangladesh is 2.1 per cent.
Pathophysiology
Insulin is produced in the pancreatic b cell. The regulation of insulin release is extremely complex, being influenced by glucose, amino acids, gut insulinogenic hormones, glucagon, neural influences, and other factors. Insulin exerts its major effects on carbohydrate homeostasis by stimulating peripheral glucose disposal and inhibiting hepatic glucose production. A variety of abnormalities in insulin biosynthesis, secretion, and action can lead to diabetes.
IDDM:
Autoimmunity plays a major role in the etiology of IDDM. Up to 90 per cent of patients with new-onset IDDM have demonstrable serum titers of islet cell antibodies. These antibodies are heterogeneous- some binding to cvtoplasmic antigens common wall islet cells and others directed against the P cell surface. The latter lyse b cells in culture in the presence of complement, consistent with a pathophysioloeic role in vivo. In humans, islet cell and anti-insulin antibodies can be detected at least several years prior to IDDM onset. Titers of these antibodies fall after the onset of clinical disease. A strong genetic component is involved in the etiology of IDDM, but several lines of evidence suggest a role for viruses in IDDM: (1) Autopsies of IDDM patients have revealed round cell infiltration of islet tissue, (2) Seasonal variation in the incidence of IDDM has been noted in some studies, (3) History of preceding viral-type illness, particularly coxsackie B and mumps, is often reported at the onset of IDDM, (4) Increased viral titers including coxsackie virus B, have been reported at or near the time of onset of disease, (5) Certain diabetogenic viruses (encephalomyocarditis M, coxsackie virus B, and rheovirus) can cause diabetes when inoculated into rodents, (6) Diabetogenic viruses can also directly infect b cells in culture, causing cell lysis and death.
NIDDM :
Abnormalities of insulin and to a lesser extent, glucagon secretion and action are central to the pathogenesis of NIDDM. Beyond familial hyperproinsulinemia and mutations in the structural gene for insulin, insulin biosynthesis is qualitatively normal in NIDDM. Majority of patients with NIDDM are both insulin deficient and insulin resistant. b cell dysfunction may be characterised by a defect in glucose recognition by islet cells. Insulin deficiency tends to be more severe in patients with longstanding disease. Although a receptor defect (decreased number) is present in most insulin-resistant NIDDM patients, this does not appear to be the major abnormality. Several postbinding defects have also been described in NIDDM ; e. g., these patients exhibit decreased b subunit tyrosine kinase activity, decreased rates of cellular glucose transport, and diminished activity. In addition, hepatic glucose production rates are also increased. This hepatic abnormality is, at least partially, due to resistance to insulin's normal restraining effect on liver glucose production. Additionally, glucagon levels are often elevated, either absolutely or relatively, and it is possible that excess glucagon stimulation also contributes to the increase in glucose production. Thus, insulin deficiency, insulin resistance, and accelerated hepatic glucose production contribute to the hyperglycemia in NIDDM.
Investigations
Oral Glucose Tolerance Test (OGTT) :
This diagnostic test, although controversial is a quite reliable test for diabetes. Several factors including infections stress, pregnancy, metabolic abnormalities, and certain drugs can impair glucose tolerance and produce abnormal results. One should screen for the possibility of these factors when using the OGTT.
Fasting Plasma Glucose /FPG) :
It a the simplest test in which blood is dravm from the patient after an overnight fast Hoaevm a normal FPG does not rule out diabetes. This test is used in nonpregnant adult patients who are neither receiving drugs nor have other diseases that could be responsible for the abnormal results.
Two-hour Postprandial Blood Glucose (2HPP) :
The 2HPP is used as a screening test in which a blood glucose level is measured two hours after the patient ingests a 100-g glucose load.
Glycosylated Hemoglobin (Hemoglobin A1) Measurements :
Glycosylated hemoglobin is abnormally high in diabetics with chronic hyperglycemia and reflects their metabolic control. In patients monitoring their own blood glucose levels, glycohemoglobin values provide a valuable check on the accuracy of monitoring. Glycohemoglobin values are also essential for adjusting therapy.
Self-monitoring of Blood Glucose and Urinalysis :
Monitoring of blood glucose by patients has allowed greater flexibility in management while achieving improved glycemic control. It involves educating the patient to perform 3 essential steps : (1) The obtaining of a drop of capillary blood from the fingertip. (2) Application of the sample to the test strip and removal at the proper time. (3) Accurate quantitation of the color developed. Patient-performed urinalysis tests are used for the evaluation of urine glucose, urine ketones, and urine protein.
Clinical Features
IDDM :
These patients usually present with relatively abrupt clinical symptoms of polyuria, polydipsia, and polyphagia. Weight loss, fatigue, and infection can often accompany the initial presentation. Because of the extreme hvpoinsulinemia and hyperglucagonemia, these patients readily develop ketosis, and the initial onset of this disease may be clinically evident as full-blown ketoacidosis. When vomiting occurs in response to worsening ketoacidosis, dehydration progresses and compensatory mechanisms become inadequate to keep serum osmolality below 320-330 mosm/1. Under these circumstances, stupor or even coma may occur. In occasional patients with slow, insidious onset of insulin deficiency, subcutaneous fat may be considerably depleted. An enlarged liver, eruptive xanthomas on the flexor surface of the limbs and on the buttocks, and lipemia retinalis indicate that chronic insulin deficiency has resulted in chylomicronemia.
NIDDM :
It typically presents with polyuria and polydipsia of several weeks' to months' duration. Polyphagia can occur but is less common, whereas weight loss, weakness, and fatigue are frequent. Dizziness, headache, and blurry vision are common accompanying complaints. In many patients no symptoms are apparent and the disease is diagnosed by routine blood or urine testing. In others, diabetes is advanced, and the presenting complaints are related to neuropathic, retinopathic, or vascular complaints. Chronic skin infections are common. Generalised pruritus and symptoms of vaginitis are frequently the initial complaints of women with NIDDM. Abdominal or upper body obesity is more closely associated with NIDDM than is lower body obesity. Ketosis is rare?
Complications
Most diabetic patients eventually experience one or more of the long-term complications of the disease. These complications arise from chronic hyperglycemia, which causes damage to small-and large-caliber blood vessels and peripheral nerves, greatly increasing the risk of heart attack, stroke, blindness, amputation, and kidney failure. Exactly how hyperglycemia causes these complications has been debated for years. Ishii and co-workers provide new support for the hypothesis that activation of the b2 isoform of protein kinase C (PKC) in vascular tissue is a key step in the cascade of events through which glucose triggers diabetic complications.
Diabetic Retinopathy :
Diabetic retinopathy is a specific microvascular complication of chronic hyperglycemia. In patients who have had diabetes for 20 years, some degree of diabetic retinopathy is found in nearly all with IDDM and in more than 60 per cent with NIDDM.
Diabetic Nephropathy :
Diabetic nephropathy accounts for nearly one third of all new cases of end-stage renal disease. The incidence of this disease is about 30 per cent in patients with IDDM and 40 per cent to 20 per cent in those with NIDDM. Although hyperglycemia appears to be an important risk factor for diabetic nephropathy, other factors have also been identified. Genetic factors, excessive protein intake, systemic hypertension, and certain metabolic abnormalities (e.g., lipoprotein abnormalities, nonenzymatic glycosylation) have been implicated in the pathogenesis of diabetic renal disease. Because of the consensus regarding the benefit of ACE inhibitors for early diabetic nephropathy, these agents should be started when microalbuminuria is confirmed and the effects of glycemic control are noted.
Diabetic Neuropathy :
The most common diabetic neuropathy is distal symmetric sensorimotor polyneuropathy. Other neuropathies, which may coexist or occur independently, include cranial mononeuropathy, isolated peripheral neuropathy, proximal motor neuropathy and autonomic neuropathy. Hyperglycemia is one of the major risk factors in development of distal symmetric sensorimotor polyneuropathy and autonomic dysfunction. Others include tallness, male sex, older age, hypertension, elevated cholesterol levels, and smoking.
The High-Risk Foot :
Advanced distal sensory, motor, and autonomic deficits are involved in the pathogenesis of most foot ulcers and resultant amputations in patients with diabetes. Typical complaints include pins-and-needles pain, shooting pain, and nocturnal exacerbations preventing sleep. Patients should be advised to refrain from walking barefoot and taught to inspect the feet and interdigital spaces daily. Shoes should accommodate any deformities and provide cushioning at the points of contact.
Diabetic Ketoacidosis :
It is a state of uncontrolled catabolism associated with insulin deficiency. In absence of insulin, hepatic glucose production accelerates and peripheral uptake by tissues is reduced. Rising glucose levels lead to an osmotic diuresis, loss of fluid and electrolytes, and dehydration. Plasma osmolality rises and renal perfusion falls. The features of ketoacidosis are those of uncontrolled diabetes with acidosis, and include prostration, hyperventilation, nausea, vomiting and abdominal pain. Diagnosis is con-firmed by demonstrating hyperglycemia with ketonemia or heavy ketonuria, and acidosis. The goals of therapy are to increase the rate of glucose utilisation by insulin-dependent tissues, to reverse ketonemia and acidosis, and to correct the depletion of water and electrolytes.
Management
Management of diabetes consists of diabetes education; nutrition and exercise plan; pharmacologic approach and insulin therapy.
Diabetes Education :
From 12 different trials it has been found that diabetes-related hospitalisations were reduced significantly in patients receiving instruction regarding self management. It is important that the educational process be well organised according to the individual patients' need and be periodically evaluated for their competence in performing urine or blood tests, mixing and injecting insulin, rotating injection sites, using the diet exchange system, and following an exercise prescription. Information should be provided about the identification of complication and their handling especially of hypoglycemic and hyperglycemic episodes. Improvement of life-style is another area where educational guidelines should be developed.
Nutritionl Diet :
Diet is the cornerstone of treatment of both Type I and Type II diabetes. It is estimated that upto 80 per cent of type II diabetes are over-weight and even a modest weight reduction of 10 pounds can markedly improve glucose tolerance. Behavioral changes in choosing and preparing food are essential for long term success. Daily calorie intake would be 30-35 kcal/kg depending upon the physical activity. It should be tailored in overweight patient. The total amount of carbohydrate in the diet should provide 50-55 per cent of total calories with fat 30-35 per cent and protein 15 per cent. Carbohydrate should be unrefined rather than simple sugars such as sucrose. Dietary fiber intake should be at least 20-35 g/day. Of fat intake, saturated, monounsaturated, polyunsaturated and cholesterol content would be daily
Exercise :
The exercise programme should be individualized and appropriate for the patient's age, coexisting medical conditions, and lifestyle. Exercise produces an improvement in insulin sensitivity or the ability of insulin to be used to drive glucose into the cell, and improves circulation. It also helps to maintain normal body weight and aids in breathing, digestion, and metabolism. Exercise may also reduce cardiovascular risk factors, such as hypertension and dyslipidemia. However, pre-exercise evaluation for silent ischemia may be necessary.
Oral Hypoglycemic Agents :
Unfortunately, in some patients, blood glucose levels continue to worsen even with diet and exercise. Causes may include noncompliance, diminishing endogenous insulin reserve, and glucose toxicity. Several agents may be considered in pharmacologic treatment of NIDDM. The choice depends on such factors as cost, side-effect profile, ease of administration, and patient age. The most recent consensus statement of the American Diabetes Association asserts that "Sulphonylureas are a rational choice to begin pharmacological intervention because almost all patients with Type II diabetes are relatively insulin deficient." Suphonylureas are inexpensive, many can be taken once daily, and have few side effects. The main concerns with their use are hypoglycemia and a tendency toward weight gain. Biguanides can also be used in NIDDM.
Mortality associated with lactic acidosis necessitated removal of Phenphormin from the market. But Metformin appears to be safer with the incidence of lactic acidosis in 0.03 cases for 1,000 patients, and it usually occurs in patients with renal disease or other risk factors. It should not be given in men and women with creatinine level 1.5 mg/dl or more and 1.4 mg/dl or more respectively and in patients with a history of acute or chronic metabolic acidosis. It should also be avoided in clinical situations associated with renal dysfunction, myocardial infarction, shock and sepsis. Other disadvantages include cost and gastrointestinal side effects. But as it does not cause hypoglycemia or weight gain, it has a favourable effect on dyslipidemia. Studies have shown that combined therapy with Metformin and Sulphonylurea have synergistic effect on glucose control. Metformin can also be used in patients who require extremely high doses of exogenous insulin, so that relatively low doses of insulin is required. Another agent recently available, Acarbose competitively inhibit intestinal brush-border alphaglucosidase required for breakdown of starches and sucrose to absorbable monosaccharides. Acarbose-Sulphonylurea combination has been found to be more effective than Sulphonylurea therapy alone. Disadvantages of Acarbose include flatulence and abdominal discomfort. Many reports have recorded the use of a class of drugs referred to as Thiazolidinediones. These agents have been shown to have an insulin-sensitising effect by improving glucose tolerance while lowering insulin levels. But their use is limited because of observed side effects. Recently, the Thiazolidinedione troglitazone has been shown to have a peripheral tissue insulin-sensitising effect with greatly reduced side effects, so the agent holds promise for future use.
A possible approach when oral therapy for NIDDM begins to fail is bedtime insulin-daytime Sulfonvlurea therapy, known as BIDS. The regimen is usually started with 0.1 to 0.2 U/kg of an intermediate-acting insulin at bedtime. The dose is increased until a fasting blood glucose level of 150 mg/dl or less is achieved. A Sulfonylurea is given during the day time. Although clinical improvement is usually seen sooner, a 4 to 6 weeks observation period may be needed to determine whether the therapy has been successful.
Appetite Suppressants :
Agents currently used to suppress appetite and promote weight loss include Phentermine HCI, Fenfluramine HCI, Fluoxetine HCl and Dexfenfluramine. These can be used in NIDDM. Ongoing studies are evaluating the potential of these agents for long-term use.
Exogenous Insulin :
Insulin is the primary mode of therapy in all patients with IDDM, and in many with NIDDM when other treatment modalities fail. In NIDDM regimens that provide 24 hour insulin should be considered with intermediate or short-acting insulin. More aggressive strategies include use of an insulin pump or long-acting insulin preparation combined with regular insulin at meals.
Diabetes Drugs
What are the types ?
nsulins may be short-acting (soluble), or modified to lengthen their action. There are 40 or more types available. Because insulin cannot be absorbed by the bowel, it must be given by injection. Much insulin is now made by genetic engineering methods; some is still extracted directly from pork or beef pancreas. There are several types of tablets. The sulphonylureas are tolbutamide, glibenclamide (Daonil, Euglucon), gliclazide (Diamicron), chlorpropamide, tolazamide (Tolanase), gliquidone (Glurenorm), glimepiride (Amaryl) and glipizide (Glibenese, Minodiab). The only biguanide is metformin (Glucophage). Acarbose (Glucobay) is also used. Guar gum (Guarem), repaglinide (Novonorm) and rosiglitazone (Avandia) are also used.
What are they for ?
They are only used to treat diabetes mellitus. Insulin is essential for so-called type 1 diabetes where the body cannot make insulin. In type 2 diabetes some insulin is still made, but not enough to satisfy the body's needs. If diet treatment alone is not fully effective, tablets are added. Sometimes insulin is also needed in type 2 diabetes.
How do they work ?
Insulin helps glucose to get into your body's cells. Inside the cells, insulin helps glucose to be changed into energy, and into other substances like proteins and fat. Sulphonylureas help the pancreas to make more insulin. They also help insulin to act on body cells. Metformin works on the cells directly, especially in muscles and liver. Insulin already there is helped to work better. Acarbose stops starches being converted to sugar in the bowel. Less sugar therefore gets into the body. Guar gum reduces absorption of carbohydrates after a meal. Repaglinide increases the body's own insulin supply and is sometimes given with another tablet such as metformin. Rosiglitazone helps the body's own insulin to work better by making the cells more sensitive to its actions. It is used together with metformin or a sulphonylurea. It can also be used with insulin injections, to improve their action.
How should they be used ?
Insulin injections are usually given at least twice a day, 15 to 30 minutes before meals. The best control of blood sugar is often achieved with short-acting insulin three times a day before main meals, with a long-acting insulin at breakfast or bed-time. Insulin can be given by syringe or by pens. In pens, insulin is loaded as cartridges just like with a fountain pen. Insulin can also be given by a pump either outside the body or implanted in it. Tablets are taken once to three times a day in type 2 diabetes when dieting alone is not enough. Follow the instructions that you have been given as to when to take your tablets in relation to meals : some should be taken before and others after meals. You should always take them regularly: not just when glucose in the blood or urine rises. Sometimes, your doctor will prescribe a combination of these drugs. This helps to improve control of the blood sugar level. Under no circumstances should you stop any drugs for diabetes unless your doctor advises it.
During Treatment …
You may need to increase doses of insulin or tablets if the blood or urine glucose levels rise. Such dose increases may be needed if you gain weight, eat more or are under stress. Bigger doses are often needed if you have an infection. You may need less insulin or tablets if you are exercising more. If you are not sure how to handle these problems, your doctor will advise how to change your own doses. You will need to adjust your doses of insulin or tablets to keep the blood glucose level as close as possible to the normal range. Insulin or sulphonylureas can lower your glucose level too far (below 2.2 mmol/l: 40 mg/dl). This causes hypoglycaemia (or "hypos"). Sweating, trembling, hunger, faintness and even coma may result. Regular meals and sometimes snacks are essential to reduce this risk. Let your doctor know if you get anything other than occasional or mild hypos. Always keep a supply of glucose such as Dextrosol or lump sugar in your pocket or bag. Any anti-diabetic tablets can cause stomach and bowel upset, usually diarrhoea. With both metformin and acarbose, these often lessen with continued use. If they persist, see your doctor. Acarbose and guar gum are particularly likely to give you a lot of wind. Occasionally the sulphonylureas can cause skin rashes or (yellow) jaundice: again, see your doctor if this happens. Metformin is not usually prescribed if you have kidney, liver or heart problems. It can then cause the serious condition of lactic acidosis. Chlorpropamide is also unsafe with kidney failure.
Drug Interference …
Alcohol can also worsen or even cause "hypos", if you eat too little. Both ACE inhibitors and beta-blockers, drugs used for blood pressure treatment, can lower blood glucose, which can be helpful or harmful. Beta-blockers can also worsen "hypos" if they occur. Water tablets (diuretics) and particularly steroids (cortisone-like tablets) can raise blood glucose, sometimes to very high levels. Doses of your anti-diabetic drug are likely to need increasing. Your doctor will guide you. Some antibiotics, anti-inflammation and antifungal drugs increase the effect of anti-diabetic tablets.
What if not taken ?
Stopping any type of anti-diabetic drug can be dangerous. Your blood glucose level would certainly rise, making you less resistant to infections. Symptoms of thirst and excessive urination may come back. Even without symptoms, prolonged high glucose levels can damage other organs, particularly the eyes, kidneys and nerves. Your blood-vessels are also more likely to get blocked by a blood clot causing a stroke or heart attack. If you stop insulin, you could become seriously ill and go into coma. If you miss even a single dose of insulin at the time of another illness, you may get quite ill.
General advice
In every case, diet remains important. Diabetes will be easier to control if you are not overweight. Any illness or new drug may affect control. Test your own glucose level more often with illness or with any change in medication. If control does change, and you are not confident of altering your own doses, ask your doctor promptly. Anti-diabetic tablets are not safe during pregnancy: you would need insulin. In low doses, oral drugs are safe during breast-feeding. If you have any questions not answered by this factsheet, please ask your doctor or pharmacist. Keep this factsheet handy in case you have to refer to it at a later date.
Klinefelter's Syndrome
Klinefelter's syndrome only occurs in males and results from a congenital abnormality of the sex chromosomes, X and Y. Normally a male has only one X and one Y chromosome and a female has two of the X-chromosomes. In Klinefelter's syndrome, two or more X-chromosomes are present in addition to one Y chromosome. The X-chromosomes contain a large amount of genetic material that has many effects beyond those that determine sex. Klinefelter's syndrome usually is not present in other family members, but occurs as a new mutation.
Manifestations of this genetic disorder are highly variable depending on the number of extra X-chromosomes. Infertility is exceedingly common if not universal, so the diagnosis often is made in the course of investigation for this problem in adult life. Many men with Klinefelter's are unusually tall due to abnormally long limbs. The testicles may be small and the breast tissue enlarged (gynecomastia).
At present, there is no treatment available that can correct the genetic abnormality. Testosterone therapy may benefit decreased libido, if that is a problem, and also may improve secondary sexual characteristics such as beard growth. According to the NIH (www.NIH.org), the XXY chromosome arrangement appears to be one of the most common genetic abnormalities known, occurring as frequently as 1 in 500 to 1 in 1,000 male births. Although the syndrome's cause, an extra sex chromosome, is widespread, the syndrome itself-the set of symptoms and characteristics that may result from having the extra chromosome-is uncommon. Many men live out their lives without ever even suspecting that they have an additional chromosome.
Recently, the term "Klinefelter syndrome" has fallen out of favor with medical researchers. Most prefer to describe men and boys having the extra chromosome as "XXY males." In addition to occasional breast enlargement, lack of facial and body hair, and a rounded body type, XXY males are more likely than other males to be overweight, and tend to be taller than their fathers and brothers.
For the most part, these symptoms are treatable. Surgery, when necessary, can reduce breast size. Regular injections of the male hormone testosterone, beginning at puberty, can promote strength and facial hair growth-as well as bring about a more muscular body type.
A far more serious symptom, however, is one that is not always readily apparent. Although they are not mentally retarded, most XXY males have some degree of language impairment. As children, they often learn to speak much later than do other children and may have difficulty learning to read and write. And while they eventually do learn to speak and converse normally, the majority tend to have some degree of difficulty with language throughout their lives. Ideally, XXY males should begin testosterone treatment as they enter puberty. XXY males diagnosed in adulthood are also likely to benefit from the hormone. A regular schedule of testosterone injections will increase strength and muscle size, and promote the growth of facial and body hair.
The vast majority of XXY males do not produce enough sperm to allow them to become fathers without medical assistance. If these men and their wives wish to become parents, they should seek counseling from a Reproductive Endocrinologist regarding their options.
However, no XXY male should automatically assume he is infertile without further testing. In a small number of cases, XXY males have been able to father children without medical assistance. Along with having cells with the XXY chromosome count, these males may also have cells with the normal XY chromosome count. If the number of XY cells in the testes is great enough, the individual should be able to father children.
Although the missing testosterone due to disfunction in the testes can be artificially supplied, the changes in the testes that lead to infertility are not preventable. However, new studies have shown that in some cases, Klinefelter males can indeed become fathers. The first question that had to be answered before further research could be done was whether or not infertile Klinefelter men produce any functional sperm at all. This question was answered in a study done by Cozzi et. al. in which cells to form spermatozoa was confirmed. With the knowledge that viable spermatozoa may exist in these men, the next step was to try to access it.
In a study conducted by Tournaye et. al., the possibility of recovering testicular spermatozoa from XXY patients for use in intracytoplasmic sperm injection (ICSI) was investigated. If spermatozoa can be recovered from Klinefelter's males, ICSI allows their partners' eggs to be impregnated and placed in the uterus for normal development. Therefore, the Klinefelter man's sexual incapacity is overcome. This is a common infertility treatment for couples. The feat in making it work in an XXY male is the actual recovery of sperm.
In four out of nine patients, spermatozoa were recovered from testicular tissue. Although the results proved this to be a fairly successful infertility treatment, the authors consider the procedure experimental with concerns for the chromosomal normality in the embryos generated by ICSI. This complex treatment involves multiple testicular biopsies and preimplantation diagnosis of embryos, making it much more complicated than it sounds.
This is an enormous step in refining infertility treatment of Klinefelter males. Although it is still experimental, it has been proven to work and exists as an option for couples capable of enduring the emotional, physical, and financial hardships of the procedure.
Resources for further information:
K' S. and Associated
P.O. Box 119
Roseville, CA 95678
Support group for XXY males as well as males with other sex chromo-some disorders. Operated by "Melissa," mother of a 12-year-old XXY boy Provides literature on XXY males and other chromosome disorders, periodic newsletter.
Works Cited
1. Cozzi J., Chevret E., Rousseaux S., Pelletier R., Benitz V., Jalbert H., Sele B. 1994. Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient. Human Genetics. 93: 32-4.
2. Staessen C., Coonen E., Van Assche E., Tournaye H., Joris H., Devroey P., Van Steirteghem A., Liebaers I. 1996. Preimplantation diagnosis for X and Y normality in embryos from three Klinefelter patients. Human Reproduction. 11: 1650-53.
3. Tournaye H., Staessen C., Liebars I., Van Assche E., Devroey P., Bonduelle M., Van Steirteghem A. 1996. Testicular sperm recovery in nine 47, XXY Klinefelter patients. Human Reproduction. 11: 1644-49.
Sexually Transmitted Diseases or STD
Sexually transmitted diseases are infections that are often, if not always, passed from person to person through sexual contact. Because sexual activity provides an easy opportunity for organisms to find new hosts, a wide variety of infectious micro-organisms can be spread by sexual contact.
Most of the infectious agents that cause sexually transmitted disease are fairly easily inactivated when exposed to a harsh environment. They are thus particularly suited to transmission by contact with mucous membranes. They may be bacteria (e.g. gonococci), spirochetes (syphilis), chlamydiae (nongonococcal urethritis, cervicitis), viruses (e.g. herpes simplex, hepatitis B virus, cytomegalovirus, AIDS virus), or protozoa (e.g. Trichomonas). In most infections caused by these agents, early lessons occur on genitalia or other sexually exposed mucous membranes; however, wide desimination may occur.
Controlling sexually transmitted diseases depend on promoting safe sex practices and providing good medical facilities for diagnosis and treatment. Educating people about how to prevent the spread of sexually transmitted diseases- especially encouraging condom use - is critical. Today treatments can rapidly cure most sexually transmitted diseases and prevent them from spreading. However, a number of new drug resistant variants of older organisms have spread widely in part because of worldwide travel, especially air travel and such mobility has been partly responsible for the rapid spread of the Human Immuno Deficiency Virus (HIV), which causes AIDS.
Except for AIDS and hepatitis B, sexually transmitted diseases can be cured or managed if they are treated early. But one, may not realise that one has an STD until it has damaged the patients reproductive system, vision, heart, or other oragans. Also, having an STD weakens the immune system and leaves one more vulnerable to other infections.
Sexually transmitted diseases (STDs) are among the most common infectious diseases in the United States and many European & Asian countries of the world today. More than 20 different STDs have been identified. Depending on the disease, the infection can be spread through any type of sexual activity involving the sex organs or the mouth; the infection can also be spread through contact with blood during sexual activity.
- STDs affect men and women of all ages and backgrounds.
- STDs have become more common, partly because young people are becoming sexually active at a younger age and are having multiple partners.
- People can pass STDs to sexual partners even if they themselves do not have any symptoms.
- Frequently, STDs cause no symptoms, especially in women.
- Health problems from STDs tend to be more severe for women than for men. Some STDs can cause pelvic infections that may lead to scarring of the reproductive organs, which can result in an ectopic pregnancy (a pregnancy outside the uterus) and infertility for women.
- STDs in women may be related to cancer of the cervix.
- STDs can be passed from a mother to her baby before, during, or immediately after birth.
- Because the method of becoming infected is similar with all STDs, a person can easily pick up more than one infection at a time.
- Experts believe that having an STD that is not AIDS increases one's risk for becoming infected with AIDS.
- Sexually Transmitted Diseases Causes
- Depending on the disease, STDs can be spread with any type of sexual activity. STDs are most often caused by viruses and bacteria.
- Sexually Transmitted Diseases Symptoms
- Common STDs have a variety of symptoms (if symptoms develop at all) and many different complications, including death.
Chlamydia
- Most common of all STDs caused by bacteria
- No symptoms in 80% of women and 50% of men
- Discharge from the vagina or the penis, burning or pain during urination
- Transmitted through vaginal, oral, or anal sexual contact
- Ectopic pregnancy and infertility for women most serious complications
- Treatable with antibiotics
- Genital herpes : One type of herpes typically causes cold sores in the mouth, and another type causes genital sores; however, each type can cause either type of infection.
- Recurring outbreaks of blisterlike sores on the genitals
- Can be transmitted from a mother to her baby during birth
- Reduction in frequency and severity of blister outbreaks with treatment but not complete elimination of infection.
Hepatitis (A, B, C, D)
- Hepatitis B most often associated with sexual contact
- Yellowish skin and eyes, fever, achy, tired, might feel like the flu
- Severe complications, including cirrhosis and liver cancer
- No cure available, remission possible with some aggressive medications
- Immunizations available to prevent hepatitis A and B
Gonorrhea
- Discharge from the vagina or the penis
- Painful urination
- Ectopic pregnancy and infertility for women most serious complications
- Treatable with antibiotics
Syphilis
- Mild symptoms, often goes undetected initially
- Starts with painless genital ulcer that goes away on its own
- Rash, fever, headache, achy joints
- Treatable with antibiotics
- More serious complications associated with later stages of disease if undetected and untreated
Chancroid
- Not common in the United States
- Causes painful ulcers on the genitals
- Can be confused with syphilis or herpes
- Treatable with antibiotics
HIV/AIDS
- Spread primarily by sexual contact and from sharing IV needles
- Can be transmitted at the time a person becomes infected with other STDs
- Fatigue, night sweats, chills or fever lasting several weeks, headaches, cough
- No current cure and generally fatal, with death usually occurring after 2-3 years; medication available to slow disease progression
Genital warts
- Caused by a virus related to skin warts
- Small, painless bumps in the genital or anal areas (sometimes in clusters that look like cauliflower)
- Various treatments available (for example, freezing or painting the warts with medication)
Pubic lice
- Very tiny insects living in pubic hair
- Can be picked up from clothing or bedding
- First notice itching in the pubic area
- Treatable with creams, anti-lice agents, and combing
Scabies
- Skin infection caused by a tiny mite
- Highly contagious
- Spread primarily by sexual contact or from contact with skin, infested sheets, towels, or furniture
- Treatment with creams
When to Seek Medical Care
A medical examination may be necessary if a person believes he or she may have an STD or if he or she may have been exposed to someone with an STD. Being seen by a doctor as soon as possible after exposure to an STD is important; these infections can easily spread to others and can have serious complications.
Go to a hospital's emergency department in these circumstances:
- If an STD problem worsens
- If a fever develops with other symptoms
- If it will be a couple of days before an appointment with a doctor
Exams and Tests
Some STDs can be diagnosed without any tests at all. Other STDs require a blood test or a sample of any unusual fluid (such as an abnormal discharge from the vagina or the penis) to be analyzed in a lab to help establish a diagnosis. Some tests are completed while a person waits; other tests require a few days before a person may obtain the results.
Medical Treatment
The treatment of an STD varies depending on the type of STD. Some STDs require a person to take antibiotic medication either by mouth or by injection; other STDs require a person to apply creams or special solutions on the skin. Often, reexamination by a doctor is necessary after the treatment to confirm that the STD is completely gone.
Some STDs, such as herpes and HIV (which leads to AIDS), cannot be cured, only controlled.
Follow-up
- Sometimes people with STDs are too embarrassed or frightened to ask for help or information. However, most STDs are easy to treat.
- The sooner a person seeks treatment and warns sexual partners about the disease, the less likely the disease will do permanent damage, be spread to others, or be passed to a baby.
If diagnosed with an STD, follow these guidelines:
- Seek treatment to stop the spread of the disease.
- Notify sexual contacts and urge them to have a checkup.
- Take all of the prescribed medication.
- Sometimes, follow-up tests are important.
- Consult a doctor with specific needs and questions.
- Avoid sexual activity while being treated for an STD.
Prevention
The best way to prevent STDs is to avoid sexual contact with others. If people decide to become sexually active, they can reduce the risk of developing an STD in these ways:
- Be abstinent (refrain from sex entirely) or be in a monogamous relationship (both sexual partners are each others' only sexual partner).
- Delay having sexual relations as long as possible. The younger people are when they become sexually active, the higher the lifetime risk for contracting an STD. The risk also increases with the number of sexual partners.
- Correctly and consistently use a male latex condom. The spermicide nonoxynol-9, once thought to protect against STDs as well as to prevent pregnancy, has been proven to be ineffective for disease prevention. Do not rely on it.
- Have regular checkups.
- Learn the symptoms of STDs.
- Avoid having sex during menstruation. (HIV is passed more easily at this time.)
- Avoid anal intercourse or use a condom.
- Avoid douching because it removes some of the natural protection in the vagina.